SEQUENCE HOMOLOGY AMONG SPERM ANTIGENS INVOLVED IN MAMMALIAN FERTILIZATION - SEARCH FOR A COMMON EPITOPE FOR IMMUNOCONTRACEPTION

被引：5

作者：

ZHU, X ^{[1
]}

NAZ, RK ^{[1
]}

机构：

[1] ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL,REPROD IMMUNOL & MOLEC BIOL LABS,BRONX,NY 10461

来源：

ARCHIVES OF ANDROLOGY | 1994年 / 33卷 / 02期

关键词：

SPERM ANTIGENS; FERTILIZATION; IMMUNOCONTRACEPTION; ANTISPERM ANTIBODIES;

D O I：

10.3109/01485019408987816

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Sequence homology was searched among the nine cDNAs/deduced amino acid sequences encoding for the eight fertilization-related sperm antigens. namely, lactate dehydrogenase (LDH-C,), galactosyltransferase (GT), SP-10, rabbit sperm autoantigen (RSA), guinea pig (g)PH-20, cleavage signal protein (CS-1), HSA-63, human (h)PH-20, and AgX-1, respectively. Most significant identity (>50%) was found between HSA-63 and SP-10 (59.8%), and between gPH-20 and hPH-20 (61.1%); followed by identity between SP-10 and GT (34.7%); and then between AgX-1 and hPH-20 (39.4%). All others had identity <25%. The significance of these sequence homologies among the sperm antigens in the development of an antisperm contraceptive vaccine is discussed.

引用

页码：141 / 144

页数：4