INTRAVENOUS PYRIDOXINE IN ACUTE ETHANOL INTOXICATION

被引：3

作者：

MARDEL, S

PHAIR, I

ODWYER, F

HENRY, JA

机构：

[1] GUYS HOSP, NATL POISONS INFORMAT SERV, W MIDLANDS POISONS UNIT, LONDON SE1 9RT, ENGLAND

[2] ABERDEEN ROYAL INFIRM, DEPT ACCID & EMERGENCY, ABERDEEN AB9 2ZB, SCOTLAND

[3] LEICESTER ROYAL INFIRM, DEPT ACCID & EMERGENCY, LEICESTER LE1 5WW, LEICS, ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 05期

关键词：

D O I：

10.1177/096032719401300507

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Intravenous pyridoxine was evaluated as an agent for the reversal of ethanol-induced central nervous depression in a randomised double blind controlled study of 108 patients presenting with a clinical diagnosis of acute ethanol intoxication to two accident and emergency departments. Level of consciousness, measured by a modified Glasgow coma scale, showed no significant change after a single 1 g dose of intravenous pyridoxine when compared to controls given saline, The mean fall in blood alcohol concentration after one hour was 33 mg dl(-1) (7.2 mmol l(-1)) in both groups suggesting that pyridoxine has no antidotal action and no short term effect on the rate of metabolism of ethanol.

引用

页码：321 / 323

页数：3

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