ACTIVITY OF DIHYDROFOLATE-REDUCTASE INHIBITORS ON THE HEPATIC STAGES OF PLASMODIUM-YOELII YOELII INVITRO

被引：10
作者：
ERIKSSON, B
COURTIER, B
BJORKMAN, A
MILTGEN, F
MAZIER, D
机构：
[1] GRP HOSP PITIE SALPETRIERE, INSERM, U313, F-75634 PARIS 13, FRANCE
[2] GRP HOSP PITIE SALPETRIERE, DEPT PARASITOL, F-75634 PARIS 13, FRANCE
[3] MUSEUM NATL HIST NAT, F-75231 PARIS 05, FRANCE
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 85卷 / 06期
关键词：
D O I：
10.1016/0035-9203(91)90429-3
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The effects of the dihydrofolate reductase inhibitors proguanil and chlorproguanil, their active metabolites cycloguanil and chlorcycloguanil, and pyrimethamine, against the hepatic stages of Plasmodium yoelii yoelii were investigated in cultured BALB/c mouse hepatocytes. Proguanil was inactive at concentrations of 10(-8) M, whereas the other compounds were fully active at this and lower concentrations. Chlorcycloguanil was the most active compound and almost completely inhibited schizont development in concentrations as low as 10(-12) M.
引用
收藏
页码：725 / 726
页数：2
相关论文
共 14 条
[1]  
BJORKMAN A, 1980, ANN TROP MED PARASIT, V74, P245
[2]  
BRADLEY DJ, 1989, BMJ-BRIT MED J, V299, P1087, DOI 10.1136/bmj.299.6707.1087
[3]   A PRELIMINARY REPORT OF THE TOXICITY AND THE ASSOCIATED BLOOD CONCENTRATIONS OF PALUDRINE IN LABORATORY ANIMALS [J].
BUTLER, R ;
DAVEY, DG ;
SPINKS, A .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1947, 2 (03) :181-188
[4]  
DAVEY D. G., 1957, TRANS ROY SOC TROP MED AND HYG, V51, P463, DOI 10.1016/0035-9203(57)90082-2
[5]   INVITRO ACTIVITY OF PROGUANIL, CHLORPROGUANIL AND THEIR MAIN METABOLITES AGAINST PLASMODIUM-FALCIPARUM [J].
ERIKSSON, B ;
LEBBAD, M ;
BJORKMAN, A .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1989, 83 (04) :488-488
[6]  
FAIRLEY NH, 1946, T ROY SOC TROP MED H, V40, P105, DOI 10.1016/0035-9203(46)90052-1
[7]  
FINK E, 1974, B WORLD HEALTH ORGAN, V50, P213
[8]   INVITRO ACTIVITY OF ANTIMALARIAL COMPOUNDS ON THE EXOERYTHROCYTIC STAGES OF PLASMODIUM-CYNOMOLGI AND PLASMODIUM-KNOWLESI [J].
FISK, TL ;
MILLET, P ;
COLLINS, WE ;
PHUC, ND .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1989, 40 (03) :235-239
[9]   A COMPARISON OF THE PYRIMETHAMINE AND CYCLOGUANIL SENSITIVITIES OF THE PRE-ERYTHROCYTIC AND ERYTHROCYTIC STAGES OF DRUG-SENSITIVE AND DRUG-RESISTANT STRAINS OF PLASMODIUM-YOELII [J].
HOWELLS, RE ;
GILLES, HM ;
BENT, NS .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1985, 79 (03) :247-251
[10]   EFFECT OF ANTIBODIES TO RECOMBINANT AND SYNTHETIC PEPTIDES ON PLASMODIUM-FALCIPARUM SPOROZOITES INVITRO [J].
MAZIER, D ;
MELLOUK, S ;
BEAUDOIN, RL ;
TEXIER, B ;
DRUILHE, P ;
HOCKMEYER, W ;
TROSPER, J ;
PAUL, C ;
CHAROENVIT, Y ;
YOUNG, J ;
MILTGEN, F ;
CHEDID, L ;
CHIGOT, JP ;
GALLEY, B ;
BRANDICOURT, O ;
GENTILINI, M .
SCIENCE, 1986, 231 (4734) :156-159
12