BIOLOGICAL AND CLINICAL ASPECTS OF INTERLEUKIN-6

被引：1064

作者：

HIRANO, T ^{[1
]}

AKIRA, S ^{[1
]}

TAGA, T ^{[1
]}

KISHIMOTO, T ^{[1
]}

机构：

[1] OSAKA UNIV, BIOMED RES CTR, DIV MOLEC ONCOL, KITA KU, OSAKA 530, JAPAN

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 12期

关键词：

D O I：

10.1016/0167-5699(90)90173-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 6(IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

引用

页码：443 / 449

页数：7

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