VISUALIZATION OF HISTAMINE-H-1 RECEPTORS IN DOG BRAIN BY POSITRON EMISSION TOMOGRAPHY

被引：13

作者：

YANAI, K

WATANABE, T

HATAZAWA, J

ITOH, M

NUNOKI, K

HATANO, K

IWATA, R

ISHIWATA, K

IDO, T

MATSUZAWA, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT PHARMACOL,AOBA KU,SENDAI,MIYAGI 980,JAPAN

[2] TOHOKU UNIV,TB & CANC RES INST,CTR CYCLOTRON & RADIOISOTOPE,SENDAI,MIYAGI 980,JAPAN

[3] TOHOKU UNIV,TB & CANC RES INST,DEPT RADIOL & NUCL MED,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

Dog; Histamine; Histamine H[!sub]1[!/sub] receptor; In vivo study; Positron emission tomography; [!sup]11[!/sup]C]Doxepin; [!sup]11[!/sup]C]Pyrilamine;

D O I：

10.1016/0304-3940(90)90244-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H1 antagonist. The results of our study indicate that it is feasible to visualize histamine H1 receptors in human brain using these 11C-labeled compounds and PET. © 1990.

引用

页码：41 / 44

页数：4

共 12 条

[1] THE BINDING OF [H-3] MEPYRAMINE TO HISTAMINE H1-RECEPTORS IN MONKEY BRAIN [J].