NMDA RECEPTOR REDOX SITES - ARE THEY TARGETS FOR SELECTIVE NEURONAL PROTECTION

被引:84
作者
GOZLAN, H
BENARI, Y
机构
[1] INSERM U-29, Ho̊pital de Port-Royal, 75014 Paris
关键词
D O I
10.1016/S0165-6147(00)89077-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
NMDA receptors play a central role in neuronal plasticity and in several pathological situations. Transient activation of this receptor triggers long-term potentiation, whereas sustained activation leads to cell death. Evidence for control of this activity by a redox site in cell cultures, brain tissues and in recombinant NMDA receptors are discussed by Henri Gozlan and Yehezkel Ben-Ari. The characteristics of this modulation and the consequences of redox state modifications on NMDA-mediated events are examined in vitro under physiological and pathological conditions. Since metabolic disorders enhance NMDA receptor function, the redox site could constitute a new target for selectively preventing in vivo the deleterious consequences of overactivation without blocking neuronal plasticity mediated by NMDA receptors.
引用
收藏
页码:368 / 374
页数:7
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