GABA-A RECEPTORS ARE DIFFERENTIALLY SENSITIVE TO ZINC - DEPENDENCE ON SUBUNIT COMPOSITION

被引：223

作者：

SMART, TG ^{[1
]}

MOSS, SJ ^{[1
]}

XIE, X ^{[1
]}

HUGANIR, RL ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 103卷 / 04期

基金：

英国惠康基金;

关键词：

GABA-A RECEPTOR; ZINC; CLONED GABA RECEPTORS; GABA RECEPTOR SUBUNITS; HIPPOCAMPUS; SYMPATHETIC GANGLIA; BENZODIAZEPINES; PATCH CLAMP;

D O I：

10.1111/j.1476-5381.1991.tb12337.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

GABA(A) receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABA(A) receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma-subunit were inhibited by zinc. Embryonic neurones also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABA(A) receptor pharmacology may be partly dependent on expression of the gamma subunit.

引用

页码：1837 / 1839

页数：3

共 10 条

[1] GENERATION OF 2 FORMS OF THE GAMMA-AMINOBUTYRIC ACIDA RECEPTOR GAMMA-2-SUBUNIT IN MICE BY ALTERNATIVE SPLICING [J].

KOFUJI, P ;

JIA, BW ;

MOSS, SJ ;

HUGANIR, RL ;

BURT, DR .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (02) :713-715

[2] BIOPHYSICAL AND PHARMACOLOGICAL PROPERTIES OF CLONED GABAA RECEPTOR SUBUNITS EXPRESSED IN XENOPUS OOCYTES [J].

LEVITAN, ES ;

BLAIR, LAC ;

DIONNE, VE ;

BARNARD, EA .

NEURON, 1988, 1 (09) :773-781

[3] GABA-A-RECEPTOR EXPRESSED FROM RAT-BRAIN ALPHA-SUBUNIT AND BETA-SUBUNIT CDNAS DISPLAYS POTENTIATION BY BENZODIAZEPINE RECEPTOR LIGANDS [J].

MALHERBE, P ;

DRAGUHN, A ;

MULTHAUP, G ;

BEYREUTHER, K ;

MOHLER, H .

MOLECULAR BRAIN RESEARCH, 1990, 8 (03) :199-208

[4] CLONED GABA RECEPTORS ARE MAINTAINED IN A STABLE CELL-LINE - ALLOSTERIC AND CHANNEL PROPERTIES [J].

MOSS, SJ ;

SMART, TG ;

PORTER, NM ;

NAYEEM, N ;

DEVINE, J ;

STEPHENSON, FA ;

MACDONALD, RL ;

BARNARD, EA .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1990, 189 (01) :77-88

[5] IMPORTANCE OF A NOVEL GABAA RECEPTOR SUBUNIT FOR BENZODIAZEPINE PHARMACOLOGY [J].

PRITCHETT, DB ;

SONTHEIMER, H ;

SHIVERS, BD ;

YMER, S ;

KETTENMANN, H ;

SCHOFIELD, PR ;

SEEBURG, PH .

NATURE, 1989, 338 (6216) :582-585

[6]

ROVIRA C, 1990, EUR J NEUROSCI, V3, P24

[7] UNCULTURED LOBSTER MUSCLE, CULTURED NEURONS AND BRAIN-SLICES - THE NEUROPHYSIOLOGY OF ZINC [J].

SMART, TG .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1990, 42 (06) :377-387

[8] DIFFERENTIAL EFFECT OF ZINC ON THE VERTEBRATE GABA-A-RECEPTOR COMPLEX [J].

SMART, TG ;

CONSTANTI, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (04) :643-654

[9] FUNCTIONAL-PROPERTIES OF RECOMBINANT RAT GABA-A RECEPTORS DEPEND UPON SUBUNIT COMPOSITION [J].

VERDOORN, TA ;

DRAGUHN, A ;

YMER, S ;

SEEBURG, PH ;

SAKMANN, B .

NEURON, 1990, 4 (06) :919-928

[10] MICROMOLAR CONCENTRATIONS OF ZN-2+ ANTAGONIZE NMDA AND GABA RESPONSES OF HIPPOCAMPAL-NEURONS [J].

WESTBROOK, GL ;

MAYER, ML .

NATURE, 1987, 328 (6131) :640-643

← 1 →