A 64KDA PROTEIN FROM MYCOBACTERIUM-BOVIS BCG SHARES THE SAME ANTIGENIC DETERMINANTS WITH LINE-10 HEPATOMA-CELLS AND HAS ANTI-LINE-10 TUMOR-ACTIVITY

被引：5

作者：

AHSAN, CR

SASAKI, J

机构：

[1] Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki

来源：

FEBS LETTERS | 1991年 / 288卷 / 1-2期

关键词：

TUMOR IMMUNOTHERAPY; SURFACE ANTIGEN; HEPATOMA CELL; MYCOBACTERIUM-BOVIS;

D O I：

10.1016/0014-5793(91)81006-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 64 kilodalton (kDa) surface protein was isolated from the water-extracted materials from Mycobacterium bovis strain BCG, the determinants of which are antigenically shared by a 64 kDa major surface antigenic component of line 10 hepatoma cells. The 64 kDa protein showed anti-line 10 tumor activity in pre-immunized guinea pigs, and this suggests that the BCG 64 kDa protein is probably identical with the tumor specific antigen.

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页码：77 / 80

页数：4

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