The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma

被引：26

作者：

Sponaas, Anne M. ^{[1
]}

Moen, Siv H. ^{[1
,2
]}

Liabakk, Nina B.

Feyzi, Emadoldin ^{[1
,3
]}

Holien, Toril ^{[1
]}

Kvam, Solveig ^{[1
]}

Groseth, Lill Anny G. ^{[1
,3
]}

Stordal, Berit ^{[1
]}

Buene, Glenn ^{[1
]}

Espevik, Terje ^{[1
,2
]}

Waage, Anders ^{[1
,3
]}

Standal, Therese ^{[1
,2
]}

Sundan, Anders ^{[1
,2
]}

机构：

[1] KG Jebsen Ctr Myeloma Res, Trondheim, Norway

[2] NTNU, Ctr Mol Inflammat Res, Dept Canc Res & Mol Med, Trondheim, Norway

[3] St Olavs Univ Hosp, Sect Hematol, Trondheim, Norway

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2015年 / 3卷 / 02期

关键词：

Apoptosis; bone marrow; multiple myeloma; monocytes;

D O I：

10.1002/iid3.53

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX3CR1(+), CD16(+)CD14 dim non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10-30% bone marrow PC.

引用

页码：94 / 102

页数：9

共 23 条

[1] Pathogenesis of Myeloma [J].

Anderson, Kenneth C. ;

Carrasco, Ruben D. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6, 2011, 6 :249-274

[2] Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells [J].

Auffray, Cedric ;

Sieweke, Michael H. ;

Geissmann, Frederic .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :669-692

[3] Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis [J].

Balakumaran, Arun ;

Robey, Pamela Gehron ;

Fedarko, Neal ;

Landgren, Ola .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2010, 10 (04) :465-480

[4] Intracellular Toll-like Receptors [J].

Blasius, Amanda L. ;

Beutler, Bruce .

IMMUNITY, 2010, 32 (03) :305-315

[5] Multiple myeloma-related deregulation of bone marrow-derived CD34+ hematopoietic stem and progenitor cells [J].

Bruns, Ingmar ;

Cadeddu, Ron-Patrick ;

Brueckmann, Ines ;

Froebel, Julia ;

Geyh, Stefanie ;

Buest, Sebastian ;

Fischer, Johannes C. ;

Roels, Frederik ;

Wilk, Christian Matthias ;

Schildberg, Frank A. ;

Huenerlituerkoglu, Ali-Nuri ;

Zilkens, Christoph ;

Jaeger, Marcus ;

Steidl, Ulrich ;

Zohren, Fabian ;

Fenk, Roland ;

Kobbe, Guido ;

Brors, Benedict ;

Czibere, Akos ;

Schroeder, Thomas ;

Trumpp, Andreas ;

Haas, Rainer .

BLOOD, 2012, 120 (13) :2620-2630

[6] The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients [J].

Cao, Yanran ;

Luetkens, Tim ;

Kobold, Sebastian ;

Hildebrandt, York ;

Gordic, Maja ;

Lajmi, Nesrine ;

Meyer, Sabrina ;

Bartels, Katrin ;

Zander, Axel R. ;

Bokemeyer, Carsten ;

Kroeger, Nicolaus ;

Atanackovic, Djordje .

EXPERIMENTAL HEMATOLOGY, 2010, 38 (10) :860-867

[7] Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target [J].

Chauhan, Dharminder ;

Singh, Ajita V. ;

Brahmandam, Mohan ;

Carrasco, Ruben ;

Bandi, Madhavi ;

Hideshima, Teru ;

Bianchi, Giada ;

Podar, Klaus ;

Tai, Yu-Tzu ;

Mitsiades, Constantine ;

Raje, Noopur ;

Jaye, David L. ;

Kumar, Shaji K. ;

Richardson, Paul ;

Munshi, Nikhil ;

Anderson, Kenneth C. .

CANCER CELL, 2009, 16 (04) :309-323

[8] FcγRIIIa Expression on Monocytes in Rheumatoid Arthritis: Role in Immune-Complex Stimulated TNF Production and Non-Response to Methotrexate Therapy [J].

Cooper, Dawn L. ;

Martin, Stephen G. ;

Robinson, James I. ;

Mackie, Sarah L. ;

Charles, Christopher J. ;

Nam, Jackie ;

Isaacs, John D. ;

Emery, Paul ;

Morgan, Ann W. .

PLOS ONE, 2012, 7 (01)

[9] Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors [J].

Cros, Jerome ;

Cagnard, Nicolas ;

Woollard, Kevin ;

Patey, Natacha ;

Zhang, Shen-Ying ;

Senechal, Brigitte ;

Puel, Anne ;

Biswas, Subhra K. ;

Moshous, Despina ;

Picard, Capucine ;

Jais, Jean-Philippe ;

D'Cruz, David ;

Casanova, Jean-Laurent ;

Trouillet, Celine ;

Geissmann, Frederic .

IMMUNITY, 2010, 33 (03) :375-386

[10] The role of bone morphogenetic proteins in myeloma cell survival [J].

Holien, Toril ;

Sundan, Anders .

CYTOKINE & GROWTH FACTOR REVIEWS, 2014, 25 (03) :343-350

← 1 2 3 →