DOES 2ND-LINE THERAPY AFFECT THE RADIOLOGICAL PROGRESSION OF RHEUMATOID-ARTHRITIS

被引：66

作者：

PULLAR, T ^{[1
]}

HUNTER, JA ^{[1
]}

CAPELL, HA ^{[1
]}

机构：

[1] UNIV GLASGOW, ROYAL INFIRM, CTR RHEUMAT DIS, DEPT MED, GLASGOW G31 2ER, SCOTLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1984年 / 43卷 / 01期

关键词：

D O I：

10.1136/ard.43.1.18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of 2nd-line drugs on radiological progression in rheumatoid arthritis is not clear, and previous studies have yielded contradictory results. Patients (67) with rheumatoid arthritis were followed up clinically and radiologically for .apprx. 2 yr (26 patients were receiving i.m. gold, 21 penicillamine, 10 levamisole, and there were 10 controls who had consistently refused 2nd-line therapy). Patients on gold and penicillamine showed improvement in erythrocyte sedimentation rate and Hb over 2 yr which was not seen in levamisole and control patients, but hand radiograph scores in all 4 groups showed statistically significant deterioration. There was a trend towards slowing of the rate of erosion in the gold and penicillamine groups in comparison with controls, but healing of erosions was extremely unusual.

引用

页码：18 / 23

页数：6

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