The Porphyromonas gingivalis ferric uptake regulator orthologue does not regulate iron homeostasis

被引：8

作者：

Butler, Catherine ^{[1
]}

Mitchell, Helen ^{[1
]}

Dashper, Stuart ^{[1
]}

Reynolds, Eric ^{[1
]}

机构：

[1] Univ Melbourne, Melbourne Dent Sch, Oral Hlth Cooperat Res Ctr, Inst Bio21, Melbourne, Vic 3010, Australia

来源：

GENOMICS DATA | 2015年 / 5卷

基金：

英国医学研究理事会;

关键词：

Porphyromonas gingivalis; Periodontal disease; Iron homeostasis; Ferric uptake regulator; Microarray;

D O I：

10.1016/j.gdata.2015.05.042

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that has an absolute requirement for iron which it transports from the host as heme and/or Fe2+. Iron transport must be regulated to prevent toxic effects from excess metal in the cell. P. gingivalis has one ferric uptake regulator (Fur) orthologue encoded in its genome called Har, which would be expected to regulate the transport and usage of iron within this bacterium. As a gene regulator, inactivation of Har should result in changes in gene expression of several genes compared to the wildtype. This dataset (GEO accession number GSE37099) provides information on expression levels of genes in P. gingivalis in the absence of Har. Surprisingly, these genes do not relate to iron homeostasis. (C) 2015 The Authors. Published by Elsevier Inc.

引用

页码：167 / 168

页数：2

共 6 条

[1] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].