GUANINE-NUCLEOTIDE EXCHANGE FACTORS - A FAMILY OF POSITIVE REGULATORS OF RAS AND RELATED GTPASES

被引：100
作者：
FEIG, LA [1 ]
机构：
[1] TUFTS UNIV,SCH MED,SACKLER SCH GRAD BIOMED SCI,BOSTON,MA 02111
来源：
CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期
关键词：
D O I：
10.1016/0955-0674(94)90137-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The past year has seen remarkable advances in our understanding of how members of the Ras superfamily of GTPases are activated. Not only have new guanine-nucleotide exchange factors (GEFs) that activate these GTPases been identified, but in some cases, the mechanisms by which GEFs are connected to events at the cell surface have also been described. We have also come to appreciate the possibilities that GEFs may be multifunctional and that they may contribute to tissue-specific regulation of their cognate GTPase.
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页码：204 / 211
页数：8
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