3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) MONOPHOSPHATE - AN INHIBITOR OF EXONUCLEOLYTIC REPAIR OF AZT-TERMINATED DNA

被引：45

作者：

HARRINGTON, JA

REARDON, JE

SPECTOR, T

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 04期

关键词：

D O I：

10.1128/AAC.37.4.918

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP might inhibit the exonuclease and trigger the toxicity of AZT by impairing the repair of AZTMP-terminated DNA.

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页码：918 / 920

页数：3

相关论文

共 24 条

[1] THE INVITRO AND INVIVO ANTI-RETROVIRUS ACTIVITY, AND INTRACELLULAR METABOLISM OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE ARE HIGHLY DEPENDENT ON THE CELL SPECIES [J].

BALZARINI, J ;

PAUWELS, R ;

BABA, M ;

HERDEWIJN, P ;

DECLERCQ, E ;

BRODER, S ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :897-903

[2] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[3] LONG-TERM TOLERANCE AND EFFICACY OF 3'-AZIDOTHYMIDINE AND 3'-FLUOROTHYMIDINE TREATMENT OF ASYMPTOMATIC MONKEYS INFECTED WITH SIMIAN IMMUNODEFICIENCY VIRUS [J].

BOTTIGER, D ;

STAHLE, L ;

LI, SL ;

OBERG, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) :1770-1772

[4]

DERSE D, 1981, J BIOL CHEM, V256, P8525

[5] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[6]

FRIDLAND A, 1990, MOL PHARMACOL, V37, P665

[7] CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXY-2',3'-DIDEHYDROTHYMIDINE, A NUCLEOSIDE ANALOG ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS [J].

HO, HT ;

HITCHCOCK, MJM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (06) :844-849

[8]

HUANG P, 1990, J BIOL CHEM, V265, P16617

[9] INVITRO BONE-MARROW TOXICITY OF NUCLEOSIDE ANALOGS AGAINST HUMAN IMMUNODEFICIENCY VIRUS [J].

INOUE, T ;

TSUSHITA, K ;

ITOH, T ;

OGURA, M ;

HOTTA, T ;

SANEYOSHI, M ;

YOSHIDA, S ;

SAITOH, H ;

TOMODA, Y ;

NAGAI, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) :576-579

[10]

KUNKEL TA, 1988, J BIOL CHEM, V263, P4450