UNIPARENTAL ORIGIN OF SEX-CHROMOSOME POLYSOMIES

被引：18

作者：

LORDASANCHEZ, I

BINKERT, F

HINKEL, KG

MOSER, H

ROSENKRANZ, W

MAECHLER, M

SCHINZEL, A

机构：

[1] UNIV ZURICH,INST MED GENET,RAMISTR 74,CH-8001 ZURICH,SWITZERLAND

[2] MED ACAD CARL GUSTAV CARUS,DIV CLIN GENET,DRESDEN,GERMANY

[3] UNIV BERN,DEPT PEDIAT,DIV MED GENET,CH-3000 BERN,SWITZERLAND

[4] GRAZ UNIV,INST MED BIOL & HUMAN GENET,A-8010 GRAZ,AUSTRIA

来源：

HUMAN HEREDITY | 1992年 / 42卷 / 03期

关键词：

SEX CHROMOSOME POLYSOMY; PARENTAL ORIGINS; NONDISJUNCTION;

D O I：

10.1159/000154066

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The parental origin of the additional sex chromosomes in 8 cases with high-order sex chromosome polysomies was determined using DNA polymorphisms. The additional sex chromosomes were paternally derived in 3 48,XXYY cases, and maternal in origin in 1 48,XXXY case and 4 49,XXXXY cases. Thus, all extra chromosomes, within a particular patient, were always derived from only one parent. Their most likely origin was successive nondisjunction at the first and second meiotic division in one germ cell. The mechanism involved remains unclear, but appears to be independent of parental ages.

引用

页码：193 / 197

页数：5

共 20 条

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