CARCINOGENIC RANKING OF AROMATIC-AMINES AND NITRO-COMPOUNDS

被引：14
作者：
CRABTREE, HC
HART, D
THOMAS, MC
WITHAM, BH
MCKENZIE, IG
SMITH, CP
机构：
[1] ICI PLC,OCCUPAT HLTH GRP,ALDERLEY PK,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
[2] ICI PLC,COLOURS & FINE CHEM,MANCHESTER M9 3DA,LANCS,ENGLAND
[3] HICKSON & WELCH LTD,CASTLEFORD WFU 2JT,W YORKSHIRE,ENGLAND
[4] CIBA GEIGY PLC,MACCLESFIELD SK10 2NX,CHESHIRE,ENGLAND
来源：
MUTATION RESEARCH | 1991年 / 264卷 / 04期
关键词：
AMINES; AROMATIC; NITRO COMPOUNDS; RANKING SCHEME;
D O I：
10.1016/0165-7992(91)90071-B
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A scheme is proposed for ranking the carcinogenicity of aromatic amines and nitro compounds based on both qualitative (weight of evidence) and quantitative (carcinogenic potency, i.e. the TD50 value) factors. The scheme has been drawn up specifically with a view to linking with workplace hygiene controls. Other essential features are that a reliable database exists for the TD50 values for many compounds and that the scheme is capable of usage by non-toxicologists. Validation of the scheme using 38 aromatic amines or nitro compounds indicates that the main objectives have been met. Extension to different chemical classes should be possible but has not been attempted in this work. An example of a potential hygiene control scheme for use alongside the carcinogenicity ranking is described.
引用
收藏
页码：155 / 162
页数：8
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