EFFECTS OF ALPRAZOLAM AND IMIPRAMINE ON PARASYMPATHETIC CARDIAC CONTROL IN PATIENTS WITH GENERALIZED ANXIETY DISORDER

被引：30

作者：

MCLEOD, DR ^{[1
]}

HOEHNSARIC, R ^{[1
]}

PORGES, SW ^{[1
]}

ZIMMERLI, WD ^{[1
]}

机构：

[1] UNIV MARYLAND, INST CHILD STUDY, COLLEGE PK, MD 20742 USA

来源：

PSYCHOPHARMACOLOGY | 1992年 / 107卷 / 04期

关键词：

IMIPRAMINE; ALPRAZOLAM; HEART RATE; BLOOD PRESSURE; CARDIAC VAGAL CONTROL; RESPIRATORY SINUS ARRHYTHMIA; HUMAN SUBJECTS; GENERALIZED ANXIETY DISORDER;

D O I：

10.1007/BF02245268

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A noninvasive measure was used to assess the effects of alprazolam, imipramine and placebo on parasympathetic (vagal) cardiac control following 6-weeks of medication in patients with generalized anxiety disorder, Flexible dosage at therapeutic levels resulted in increased heart rate and blood pressure and in decreased cardiac vagal control in patients receiving imipramine but not alprazolam or placebo, About 50% of the variance in heart rate changes and changes in mean arterial blood pressure following treatment with imipramine could be accounted for by changes in cardiac vagal control. Decreased cardiac vagal control can now be added to the list of cardiovascular changes seen following several weeks of treatment with imipramine.

引用

页码：535 / 540

页数：6

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