MECHANISM OF NEOCARZINOSTATIN ACTION - ROLE OF DNA MICROSTRUCTURE IN DETERMINATION OF CHEMISTRY OF BISTRANDED OXIDATIVE DAMAGE

被引:361
作者
GOLDBERG, IH
机构
[1] Department of Biological Chemistry, Department of Molecular Pharmacology, Harvard Medical School, Boston
关键词
NON-PROTEIN CHROMOPHORE; ANTITUMOR ANTIBIOTIC NEOCARZINOSTATIN; DEOXYRIBONUCLEIC-ACID; SUGAR DAMAGE; STRAND SCISSION; BASE RELEASE; NAPHTHALENECARBOXYLIC ACID; MEDIATED DEGRADATION; SECONDARY STRUCTURE; SODIUM-BOROHYDRIDE;
D O I
10.1021/ar00007a001
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:191 / 198
页数:8
相关论文
共 87 条
[81]   OXIDATIVE TRIGGERING FOR AROMATIZATION OF THE NEOCARZINOSTATIN CHROMOPHORE [J].
TANAKA, T ;
FUJIWARA, K ;
HIRAMA, M .
TETRAHEDRON LETTERS, 1990, 31 (41) :5947-5950
[82]  
von Sonntag C., 1987, The Chemical Basis of Radiation Biology, P57
[83]   BASE SPECIFICITY IN INTERACTION OF POLYNUCLEOTIDES WITH ANTIBIOTIC DRUGS [J].
WARD, DC ;
REICH, E ;
GOLDBERG, IH .
SCIENCE, 1965, 149 (3689) :1259-&
[84]  
WARDMAN P, 1987, RADIAT PHYS CHEM, V30, P423
[85]   STUDIES ON DNA-ACTIVE AGENTS - THE SYNTHESIS OF THE PARENT CARBOCYCLIC SUBUNIT OF NEOCARZINOSTATIN CHROMOPHORE-A [J].
WENDER, PA ;
HARMATA, M ;
JEFFREY, D ;
MUKAI, C ;
SUFFERT, J .
TETRAHEDRON LETTERS, 1988, 29 (08) :909-912
[86]   SELECTIVE STRAND SCISSION BY INTERCALATING DRUGS AT DNA BULGES [J].
WILLIAMS, LD ;
GOLDBERG, IH .
BIOCHEMISTRY, 1988, 27 (08) :3004-3011
[87]   CALICHEAMICIN-GAMMA-1-I - AN ANTITUMOR ANTIBIOTIC THAT CLEAVES DOUBLE-STRANDED DNA SITE SPECIFICALLY [J].
ZEIN, N ;
SINHA, AM ;
MCGAHREN, WJ ;
ELLESTAD, GA .
SCIENCE, 1988, 240 (4856) :1198-1201