SERUM OSTEOCALCIN (BGP) LEVELS IN NORMAL MEN - A LONGITUDINAL EVALUATION REVEALS AN AGE-ASSOCIATED INCREASE

被引：24
作者：
ORWOLL, ES
DEFTOS, LJ
机构：
[1] OREGON HLTH SCI UNIV,PORTLAND,OR 97201
[2] VET ADM MED CTR,SAN DIEGO,CA 92161
[3] UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 1990年 / 5卷 / 03期
关键词：
D O I：
10.1002/jbmr.5650050309
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake. Copyright © 1990 ASBMR
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页码：259 / 262
页数：4
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