IDENTIFICATION OF HETEROLOGOUS MONOCLONAL-ANTIBODIES THAT CROSS-REACT WITH CERVINE LEUKOCYTE SUBPOPULATIONS

被引：9
作者：
BUCHAN, GS
GRIFFIN, JFT
机构：
[1] Deer Research Laboratory, Department Microbiology, University of Otago
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 24卷 / 03期
关键词：
D O I：
10.1016/0165-2427(90)90040-Y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The degree to which cross-reactivity between monoclonal antibodies developed against cells of the human, mouse, bovine and ovine immune systems, and cells of the cervine immune system occurs was investigated. It was found that within the ruminants a considerable degree of cross-reactivity does exist while there is virtually none between the cervine and murine or human systems. The highest incidence of cross-reactivity was found between ovine monoclonals and cervine leukocytes (46% cross-reactive) with 25% of bovine monoclonal antibodies cross-reacting with deer leukocytes. Ovine monoclonals were found to be the most useful in identifying a wide range of cervine leukocyte subpopulations. Bioassays showed that ovine anti-class I and II monoclonals detected molecules on cervine leukocytes that are functionally similar to MHC antigens. The possibility that cross-reactive monoclonals detect similar subpopulations in both the homologous and heterologous species is discussed. © 1990.
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页码：247 / 257
页数：11
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