OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES

被引：42

作者：

GAGNON, R

GROGAN, G

GROUSSAIN, E

PEDRAGOSAMOREAU, S

RICHARDSON, PF

ROBERTS, SM

WILLETTS, AJ

ALPHAND, V

LEBRETON, J

FURSTOSS, R

机构：

[1] UNIV EXETER,DEPT BIOL SCI,EXETER EX4 4QD,DEVON,ENGLAND

[2] CNRS,URA 1320,CHIM ORGAN & BIOORGAN GRP,F-13288 MARSEILLE 9,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 20期

关键词：

D O I：

10.1039/p19950002527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of the prochiral cyclobutanones 1-5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6-10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

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页码：2527 / 2528

页数：2

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