GLUCOSE ALTERS RAT-LIVER S9-MEDIATED MUTAGENESIS, METABOLISM AND DNA-BINDING OF AFLATOXIN-B1

被引：4
|
作者：
TEEL, RW
STROTHER, A
机构：
[1] Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda
来源：
CANCER LETTERS | 1990年 / 54卷 / 03期
关键词：
aflatoxin; glucose; metabolism; mutagenesis;
D O I：
10.1016/0304-3835(90)90039-Z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The administration of 30% glucose in drinking water to rats for 48 h caused a significant increase in the hepatic S9-mediated mutagenicity of aflatoxin B1, in Salmonella typhimurium TA100 and in the binding of aflatoxin B1, to calf thymus DNA in vitro. These effects correlated with a reduction in the metabolism and detoxification of aflatoxin B1, by S9 from glucose-treated rats and suggest that the oral intake of sugar may affect the hepatocarcinogenicity of aflatoxin B1. © 1990.
引用
收藏
页码：163 / 169
页数：7
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