ENHANCED SYNTHESIS OF HEAT-SHOCK PROTEINS AND AUGMENTED THERMOTOLERANCE AFTER INDUCTION OF DIFFERENTIATION IN HL-60 HUMAN LEUKEMIA-CELLS

被引：16

作者：

YUFU, Y

NISHIMURA, J

IDEGUCHI, H

NAWATA, H

机构：

[1] Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka, 812

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Differentiation; Heat shock protein; HL-60; cell; Thermotolerance;

D O I：

10.1016/0014-5793(90)81001-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of the induction of differentiation were investigated on the expression of heat shock proteins (hsps) and thermotolerance. The synthesis of the major hsps in response to heat stress was markedly enhanced in HL-60 human leukemia cells after differentiation. An increased amount of mRNA transcripts for hsp70 was also noted. In addition, induction of differentiation resulted in acquisition of greater resistance to heat, which may be advantageous since cells in the peripheral blood must survive many stresses. © 1990.

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页码：173 / 176

页数：4

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