EFFECTS OF CHRONIC OUABAIN TREATMENT ON [H-3]OUABAIN BINDING-SITES AND ELECTROGENIC COMPONENT OF MEMBRANE-POTENTIAL IN CULTURED RAT MYOTUBES

被引：26

作者：

BRODIE, C ^{[1
]}

SAMPSON, SR ^{[1
]}

机构：

[1] BAR ILAN UNIV, DEPT LIFE SCI, IL-52100 RAMAT GAN, ISRAEL

来源：

BRAIN RESEARCH | 1985年 / 347卷 / 01期

关键词：

D O I：

10.1016/0006-8993(85)90896-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of incubation of cultured rat skeletal myotubes in ouabain were studied on the number of [3H]ouabain binding sites and electrogenic component of membrane potential. Ouabain treatment for 2-6 days increased the number of binding sites, resting membrane potential (Em) and the ouabain-sensitive component of Em in the muscle cells. The findings strengthen the idea that Na,K-ATPase has an important role in regulation of Em in cultured skeletal muscle and suggest that Na-K pump inhibition during development may be a regulatory mechanism for cellular synthesis of Na,K-ATPase.

引用

页码：121 / 123

页数：3

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