THE RELATIONSHIP BETWEEN CLINICAL AND BIOCHEMICAL-CHANGES FOLLOWING NEUROLEPTIC TREATMENT IN SCHIZOPHRENIA

被引：8

作者：

COOPER, SJ ^{[1
]}

LEAHEY, W ^{[1
]}

LIDDLE, J ^{[1
]}

KING, DJ ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST, DEPT THERAPEUT & PHARMACOL, BELFAST BT9 7BL, ANTRIM, NORTH IRELAND

来源：

SCHIZOPHRENIA RESEARCH | 1990年 / 3卷 / 04期

关键词：

(Schizophrenia); Dopamine; Homovanillic acid; Neuroleptic drug;

D O I：

10.1016/0920-9964(90)90007-T

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical changes occurring in the patients. The results can be explained in terms of dopamine receptor changes in a way that is compatible with the Dopamine Hypothesis for schizophrenia. © 1990.

引用

页码：261 / 267

页数：7

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