STUDYING DNA-PROTEIN INTERACTIONS USING NMR

被引：6
|
作者：
RUSSU, IM
机构：
[1] I.M. Russu is at the Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown
来源：
TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 03期
关键词：
D O I：
10.1016/0167-7799(91)90032-D
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
NMR spectroscopy is emerging as a powerful tool in molecular biology and biotechnology; one aspect of which is the use of one- and two-dimensional NMR methodologies to investigate the interactions of proteins with DNA. The dynamic and structural information which NMR can provide, on the changes in conformation and molecular flexibility, complements X-ray crystallography data and enables mechanistic models of DNA-protein interactions to be formulated.
引用
收藏
页码：96 / 104
页数：9
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