DETERMINATION OF A CARDIAC ANTIARRHYTHMIC, TRICYCLIC ANTIPSYCHOTICS AND ANTIDEPRESSANTS IN HUMAN AND ANIMAL URINE BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY USING A BILE-SALT

被引：27

作者：

AUMATELL, A ^{[1
]}

WELLS, RJ ^{[1
]}

机构：

[1] AUSTRALIAN GOVT ANALYT LAB,PYMBLE,NSW 2073,AUSTRALIA

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 669卷 / 02期

关键词：

D O I：

10.1016/0378-4347(95)00125-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A micellar electrokinetic capillary chromatographic method based on the use of sodium taurodeoxycholate has been developed to detect and quantitate a total of 26 tricyclic drugs. Detection limits in urine down to 4 ng/ml have been obtained. The method uses a simple liquid-liquid extraction and recovery of analytes followed by ultraviolet detection.

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页码：331 / 344

页数：14

相关论文

共 30 条

[1] ENANTIOMERIC DIFFERENTIATION OF A WIDE-RANGE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY USING A BILE-SALT [J].

AUMATELL, A ;

WELLS, RJ .

JOURNAL OF CHROMATOGRAPHY A, 1994, 688 (1-2) :329-337

[2] CHIRAL DIFFERENTIATION OF THE OPTICAL ISOMERS OF RACEMETHORPHAN AND RACEMORPHAN IN URINE BY CAPILLARY ZONE ELECTROPHORESIS [J].

AUMATELL, A ;

WELLS, RJ .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1993, 31 (12) :502-508

[3]

BALDESSARINI RJ, 1991, NEW ENGL J MED, V324, P746

[4] THE DETERMINATION OF THE GEOMETRIC ISOMERS AND RELATED IMPURITIES OF DOTHIEPIN IN A PHARMACEUTICAL PREPARATION BY CAPILLARY ELECTROPHORESIS [J].

CLARK, BJ ;

BARKER, P ;

LARGE, T .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (10-12) :723-726

[5] DRUG-MONITORING OF CLOMIPRAMINE AND DESMETHYLCLOMIPRAMINE IN DEPRESSED-PATIENTS USING A NEW LIQUID-CHROMATOGRAPHIC ASSAY [J].

DIQUET, B ;

THOMARE, P ;

BOCQUENTIN, M ;

DIVINE, C .

BIOMEDICAL CHROMATOGRAPHY, 1993, 7 (02) :59-63

[6] DETERMINATION OF TRIMIPRAMINE AND ITS DEMETHYLATED AND HYDROXYLATED METABOLITES IN PLASMA BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

EAP, CB ;

KOEB, L ;

BAUMANN, P .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 652 (01) :97-103

[7]

EWING A G, 1989, Analytical Chemistry, V61, P292

[8] TRICYCLIC ANTIDEPRESSANT OVERDOSE - A REVIEW [J].

FROMMER, DA ;

KULIG, KW ;

MARX, JA ;

RUMACK, B .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (04) :521-526

[9]

Goldnik A, 1991, Acta Pol Pharm, V48, P5

[10] CLOZAPINE PLASMA-LEVELS DETERMINED BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION [J].

HARING, C ;

HUMPEL, C ;

AUER, B ;

SARIA, A ;

BARNAS, C ;

FLEISCHHACKER, W ;

HINTERHUBER, H .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 428 (01) :160-166