INFLUENCE OF NEOADJUVANT POLYCHEMOTHERAPY ON NATURAL-KILLER-CELL ACTIVITY IN PATIENTS WITH LOCALLY ADVANCED CERVICAL SQUAMOUS CARCINOMA

Peripheral blood natural killer (NK) cell activity against K562 tumor line was monitored in 16 patients with locally advanced squamous cervical carcinoma (II and Ill FIGO stages) during neoadjuvant polychemotherapy (cisplatin at 80 mg/m2 and blemycin at 30 mg/m2). There was a significant progressive decrease in NK activity during the three cycles of antiblastic treatment (P = 0.008) without significant depletion of NK cell (CD56 and CD16 monoclonal antibody positive cell percentage and absolute number). A significant relationship was shown between basal NK activity levels and response to polychemotherapy; in fact, nonresponder patients had a significantly lower mean value of NK activity before polychemotherapy than responders (P = 0.044). In conclusion, NK activity declines as a result of antiblastic therapy; although polychemotherapy reduces tumor spread, its antineoplastic action may be affected by this decreased immune reactivity. (C) 1994 Academic Press, Inc.