ANTIULCER AGENTS .1. GASTRIC ANTISECRETORY AND CYTOPROTECTIVE PROPERTIES OF SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES

被引：148

作者：

KAMINSKI, JJ

BRISTOL, JA

PUCHALSKI, C

LOVEY, RG

ELLIOTT, AJ

GUZIK, H

SOLOMON, DM

CONN, DJ

DOMALSKI, MS

WONG, SC

GOLD, EH

LONG, JF

CHIU, PJS

STEINBERG, M

MCPHAIL, AT

机构：

[1] Pharmaceutical Research Division, Schering-Plough Corporation, Bloomfield, New Jersey

[2] Department of Chemistry, Duke University, Durham, North, Carolina

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 07期

关键词：

D O I：

10.1021/jm00145a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of antiulcer agents, the substituted imidazo[1, 2-a]pyridines, is described. The present compounds are not histamine (H2) receptor antagonists nor are they prostaglandin analogues, yet they exhibit both gastric antisecretory and cytoprotective properties. The mechanism of gastric antisecretory activity may involve inhibition of the H+/K+-ATPase enzyme. Structure-activity studies led to the identification of 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazo[1, 2-a] pyridine, SCH 28080 (27), which was selected for further development and clinical evaluation. © 1985, American Chemical Society. All rights reserved.

引用

页码：876 / 892

页数：17

共 44 条

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