TAMM-HORSFALL GLYCOPROTEIN - ROLE IN INHIBITION AND PROMOTION OF RENAL CALCIUM-OXALATE STONE FORMATION STUDIED WITH FOURIER-TRANSFORM INFRARED-SPECTROSCOPY

被引：0

作者：

KNORLE, R

SCHNIERLE, P

KOCH, A

BUCHHOLZ, NP

HERING, F

SEILER, H

ACKERMANN, T

RUTISHAUSER, G

机构：

[1] UNIV BASEL,INST INORGAN CHEM,CH-4056 BASEL,SWITZERLAND

[2] UNIV BASEL HOSP,KANTONSSPITAL,DEPT SURG,UROL CLIN,CH-4031 BASEL,SWITZERLAND

[3] KANTONSSPITAL BADEN,UROL CLIN,CH-5404 BADEN,SWITZERLAND

来源：

CLINICAL CHEMISTRY | 1994年 / 40卷 / 09期

关键词：

GLYCATED PROTEINS; SIALIC ACID; KIDNEY STONES; URINE; UROMODULIN;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Tamm-Horsfall glycoprotein (THP) from healthy probands inhibits the precipitation of calcium oxalate, whereas THP from individuals who repeatedly develop calcium oxalate stones has no effect or even promotes precipitation. Using Fourier-transform infrared spectroscopy, we found a structural differentiation between these functionally different THPs: a decisive difference in sialic acid content. Quantitative analysis for sialic acid showed the same results. THP from healthy probands had a high sialic acid content (51 +/- 9 g/kg), whereas THP from recurrent stone formers had a decreased sialic acid content (21 +/- 4 g/kg). This explains the dual role of THP in the precipitation of calcium oxalate and the formation of renal stones and shows the importance of glycosylation in the function of this glycoprotein.

引用

页码：1739 / 1743

页数：5

共 11 条

[1] THE ROLE PLAYED BY TAMM-HORSFALL GLYCOPROTEIN IN CALCIUM-OXALATE NEPHROLITHIASIS
GAMBARO, G
BAGGIO, B
FAVARO, S
CICERELLO, E
MARCHINI, F
BORSATTI, A
NEPHROLOGIE, 1984, 5 (04): : 171 - 172
[2] POSSIBLE ROLE OF TAMM-HORSFALL GLYCOPROTEIN IN CALCIUM-OXALATE CRYSTALLIZATION
YOSHIOKA, T
KOIDE, T
UTSUNOMIYA, M
ITATANI, H
OKA, T
SONODA, T
BRITISH JOURNAL OF UROLOGY, 1989, 64 (05): : 463 - 467
[3] EXCRETION OF TAMM-HORSFALL GLYCOPROTEIN IN CALCIUM-OXALATE KIDNEY-STONE FORMERS
TRINHTRANGTAN, MM
DAUDON, M
LACOUR, B
JUNGERS, P
BANKIR, L
KIDNEY INTERNATIONAL, 1990, 37 (01) : 462 - 462
[4] THE ROLE OF TAMM-HORSFALL GLYCOPROTEIN AND NEPHROCALCIN IN CALCIUM-OXALATE MONOHYDRATE CRYSTALLIZATION PROCESSES
HESS, B
SCANNING MICROSCOPY, 1991, 5 (03) : 689 - 696
[5] THE INHIBITION OF CALCIUM-OXALATE CRYSTAL-GROWTH BY CHONDROITIN SULFATES, HEPARIN, PENTOSAN POLYSULFATE AND TAMM-HORSFALL GLYCOPROTEIN
FELLSTROM, B
DANIELSON, BG
LJUNGHALL, S
WIKSTROM, B
UROLOGICAL RESEARCH, 1984, 12 (01): : 81 - 82
[6] STRUCTURAL ABNORMALITIES OF URINARY TAMM-HORSFALL GLYCOPROTEIN (THP) AMONG FAMILY MEMBERS OF A CALCIUM-OXALATE KIDNEY-STONE FORMER (SF)
HESS, B
NAKAGAWA, Y
COE, FL
KIDNEY INTERNATIONAL, 1989, 35 (01) : 382 - 382
[7] SURFACE HYDRATION OF AQUEOUS CALCIUM MINERALS AS STUDIED BY FOURIER-TRANSFORM RAMAN AND INFRARED-SPECTROSCOPY
HOLMGREN, A
WU, LM
FORSLING, W
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1994, 50 (11): : 1857 - 1869
[8] A SIMPLE DIAGNOSTIC METHOD FOR THE DIFFERENTIATION OF TAMM-HORSFALL GLYCOPROTEINS FROM HEALTHY PROBANDS AND THOSE FROM RECURRENT CALCIUM-OXALATE RENAL STONE FORMERS
SCHNIERLE, P
EXPERIENTIA, 1995, 51 (11): : 1068 - 1072
[9] FORMATION OF PHENOLIC RESINS - MECHANISM AND TIME-DEPENDENCE OF THE REACTION OF PHENOL AND HEXAMETHYLENETETRAMINE AS STUDIED BY C-13 NUCLEAR MAGNETIC-RESONANCE AND FOURIER-TRANSFORM INFRARED-SPECTROSCOPY
SOJKA, SA
WOLFE, RA
GUENTHER, GD
MACROMOLECULES, 1981, 14 (05) : 1539 - 1543
[10] CARBON-MONOXIDE AND CARBON-DIOXIDE ADSORPTION ON CERIUM OXIDE STUDIED BY FOURIER-TRANSFORM INFRARED-SPECTROSCOPY .1. FORMATION OF CARBONATE SPECIES ON DEHYDROXYLATED CEO2 AT ROOM-TEMPERATURE
LI, C
SAKATA, Y
ARAI, T
DOMEN, K
MARUYA, K
ONISHI, T
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1989, 85 : 929 - 943

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