REGIONAL LOCALIZATION OF THE HEPATOCYTE GROWTH-FACTOR (HGF) GENE TO HUMAN CHROMOSOME-7 BAND Q21.1

被引：40

作者：

FUKUYAMA, R

ICHIJOH, Y

MINOSHIMA, S

KITAMURA, N

SHIMIZU, N

机构：

[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,35 SHINANOMACHI,SHINJUKU KU,TOKYO 160,JAPAN

[2] KANSAI MED UNIV,INST LIVER RES,MORIGUCHI,OSAKA 570,JAPAN

来源：

GENOMICS | 1991年 / 11卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90149-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hepatocyte growth factor (HGF) is a polypeptide involved in liver regeneration. Its amino acid sequence and gene structure are similar to those of coagulation-related serine proteases. We have used a cDNA clone of HGF and flow-sorted human chromosomes to assign this gene to chromosome 7. Fluorescence in situ hybridization of the HGF genomic clones to human metaphase chromosome spreads showed the localization of this gene to 7q21. Estimation of fluorescent signals relative to arbitrary reference points (ARPs) allowed further localization to 7q21.1. © 1991.

引用

收藏

页码：410 / 415

页数：6

相关论文

共 20 条

[1] CDNA SEQUENCE AND CHROMOSOMAL LOCALIZATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR A-CHAIN AND ITS EXPRESSION IN TUMOR-CELL LINES [J].

BETSHOLTZ, C ;

JOHNSSON, A ;

HELDIN, CH ;

WESTERMARK, B ;

LIND, P ;

URDEA, MS ;

EDDY, R ;

SHOWS, TB ;

PHILPOTT, K ;

MELLOR, AL ;

KNOTT, TJ ;

SCOTT, J .

NATURE, 1986, 320 (6064) :695-699

[2] PLATELET-DERIVED GROWTH FACTOR-A CHAIN - GENE STRUCTURE, CHROMOSOMAL LOCATION, AND BASIS FOR ALTERNATIVE MESSENGER-RNA SPLICING [J].

BONTHRON, DT ;

MORTON, CC ;

ORKIN, SH ;

COLLINS, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1492-1496

[3]

FRANK SL, 1988, HUM GENET, V79, P352

[4] INTERFERON BETA-2/B-CELL STIMULATORY FACTOR TYPE-2 SHARES IDENTITY WITH MONOCYTE-DERIVED HEPATOCYTE-STIMULATING FACTOR AND REGULATES THE MAJOR ACUTE PHASE PROTEIN RESPONSE IN LIVER-CELLS [J].

GAULDIE, J ;

RICHARDS, C ;

HARNISH, D ;

LANSDORP, P ;

BAUMANN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7251-7255

[5] PURIFICATION AND PARTIAL CHARACTERIZATION OF HEPATOCYTE GROWTH-FACTOR FROM PLASMA OF A PATIENT WITH FULMINANT HEPATIC-FAILURE [J].

GOHDA, E ;

TSUBOUCHI, H ;

NAKAYAMA, H ;

HIRONO, S ;

SAKIYAMA, O ;

TAKAHASHI, K ;

MIYAZAKI, H ;

HASHIMOTO, S ;

DAIKUHARA, Y .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (02) :414-419

[6] HIGH-RESOLUTION MAPPING OF HUMAN CHROMOSOME-11 BY INSITU HYBRIDIZATION WITH COSMID CLONES [J].

LICHTER, P ;

TANG, CJC ;

CALL, K ;

HERMANSON, G ;

EVANS, GA ;

HOUSMAN, D ;

WARD, DC .

SCIENCE, 1990, 247 (4938) :64-69

[7] THE GENE FOR THE LP(A)-SPECIFIC GLYCOPROTEIN IS CLOSELY LINKED TO THE GENE FOR PLASMINOGEN ON CHROMOSOME-6 [J].

LINDAHL, G ;

GERSDORF, E ;

MENZEL, HJ ;

DUBA, C ;

CLEVE, H ;

HUMPHRIES, S ;

UTERMANN, G .

HUMAN GENETICS, 1989, 81 (02) :149-152

[8] TRANSFORMING GROWTH FACTOR-ALPHA MAY BE A PHYSIOLOGICAL REGULATOR OF LIVER-REGENERATION BY MEANS OF AN AUTOCRINE MECHANISM [J].

MEAD, JE ;

FAUSTO, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) :1558-1562

[9] LIVER-REGENERATION - MOLECULAR MECHANISMS OF GROWTH-CONTROL [J].

MICHALOPOULOS, GK .

FASEB JOURNAL, 1990, 4 (02) :176-187

[10] ISOLATION OF GIANT DNA FRAGMENTS FROM FLOW-SORTED HUMAN-CHROMOSOMES [J].

MINOSHIMA, S ;

KAWASAKI, K ;

FUKUYAMA, R ;

MAEKAWA, M ;

KUDOH, J ;

SHIMIZU, N .

CYTOMETRY, 1990, 11 (04) :539-546