Cerebral arteriovenous malformation presenting with polycythemia vera: A case report and literature review

被引：1
作者：
Sarni, Mairaj T. [1 ]
Bohnsted, Bradley N. [1 ]
Hattab, Eyas M. [2 ,3 ]
Markham, Raymond [4 ,5 ]
Cohen-Gadol, Aaron A. [1 ]
机构：
[1] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[3] IU Hlth Pathol Lab, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[4] Indiana Univ, Sch Med, Amer Hlth Network, Indianapolis, IN 46202 USA
[5] Indiana Univ, Sch Med, Dept Med, Sect Hematol & Oncol, Indianapolis, IN 46202 USA
来源：
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS | 2013年 / 4卷 / 10期
关键词：
Arteriovenous malformation; Polycythemia; Erythropoietin; Microsurgical resection; Neurosurgical procedures;
D O I：
10.1016/j.ijscr.2013.06.019
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
INTRODUCTION: Cerebral arteriovenous malformations (AVM) usually present with headache, hemorrhage, or seizure. Erythropoietin (EPO) has demonstrated protective effects against ischemia within the CNS. PRESENTATION OF CASE: The authors report a patient with a cerebral AVM and concurrent polycythemia associated with elevated serum EPO. Systemic EPO levels declined acutely after resection of the patient's AVM, and the polycythemia resolved in the following months. DISCUSSION: Polycythemia secondary to a cerebral AVM, in the absence of extra-cerebral vascular lesions, has not been described in the literature. CONCLUSION: The authors explore the mechanisms by which this patient's cerebral AVM could have induced EPO production within the brain, manifesting as polycythemia. (C) 2013 The Authors. Published by Elsevier Ltd on behalf of Surgical Associates Ltd.
引用
收藏
页码：813 / 817
页数：5
相关论文
共 19 条
  • [1] A potential role for erythropoietin in focal permanent cerebral ischemia in mice
    Bernaudin, M
    Marti, HH
    Roussel, S
    Divoux, D
    Nouvelot, A
    MacKenzie, E
    Petit, E
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) : 643 - 651
  • [2] Arteriovenous malformations
    Fleetwood, IG
    Steinberg, GK
    [J]. LANCET, 2002, 359 (9309) : 863 - 873
  • [3] Ten-Year Detection Rate of Brain Arteriovenous Malformations in a Large, Multiethnic, Defined Population
    Gabriel, Rodney A.
    Kim, Helen
    Sidney, Stephen
    McCulloch, Charles E.
    Singh, Vineeta
    Johnston, S. Claiborne
    Ko, Nerissa U.
    Achrol, Achal S.
    Zaroff, Jonathan G.
    Young, William L.
    [J]. STROKE, 2010, 41 (01) : 21 - 26
  • [4] Erythropoietin and the nervous system
    Genc, S
    Koroglu, TF
    Genc, K
    [J]. BRAIN RESEARCH, 2004, 1000 (1-2) : 19 - 31
  • [5] Acute neurological events in a patient with secondary polycythaemia and arteriovenous malformations
    Gill, DS
    Ng, CK
    Ng, KS
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 99 (01) : 137 - 139
  • [6] Flow-dependent regulation of angiopoietin-2
    Goettsch, Winfried
    Gryczka, Corina
    Korff, Thomas
    Ernst, Evelyn
    Goettsch, Claudia
    Seebach, Jochen
    Schnittler, Hans-Joachim
    Augustin, Hellmut G.
    Morawietz, Henning
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2008, 214 (02) : 491 - 503
  • [7] Kim H, 2011, ACTA NEUROCHIR SUPPL, V111, P83, DOI 10.1007/978-3-7091-0693-8_14
  • [8] Biology of Vascular Malformations of the Brain
    Leblanc, Gabrielle G.
    Golanov, Eugene
    Awad, Issam A.
    Young, William L.
    [J]. STROKE, 2009, 40 (12) : E694 - E702
  • [9] Erythropoietin gene expression in human, monkey and murine brain
    Marti, HH
    Wenger, RH
    Rivas, LA
    Straumann, U
    Digicaylioglu, M
    Henn, V
    Yonekawa, Y
    Bauer, C
    Gassmann, M
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (04) : 666 - 676
  • [10] Meek Mary E, 2011, Semin Intervent Radiol, V28, P24, DOI 10.1055/s-0031-1273937
12