THE CANDIDATE PROTOONCOGENE BCL-3 ENCODES A TRANSCRIPTIONAL COACTIVATOR THAT ACTIVATES THROUGH NF-KAPPA-B P50 HOMODIMERS

被引：354
作者：
FUJITA, T [1 ]
NOLAN, GP [1 ]
LIOU, HC [1 ]
SCOTT, ML [1 ]
BALTIMORE, D [1 ]
机构：
[1] ROCKEFELLER UNIV,NEW YORK,NY 10021
来源：
GENES & DEVELOPMENT | 1993年 / 7卷 / 7B期
关键词：
NF-KAPPA-B; P50; I-KAPPA-B; TRANSCRIPTION; COACTIVATOR;
D O I：
10.1101/gad.7.7b.1354
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with IkappaB-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of IkappaB-alpha, the bcl-3 gene product superactivates NF-kappaB p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappaB motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.
引用
收藏
页码：1354 / 1363
页数：10
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