DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES

被引:1015
作者
DERVAN, PB
机构
[1] California Institute of Technology, Pasadena, CA 91125, United States
关键词
BIOLOGICAL MATERIALS - DNA - PROTEINS;
D O I
10.1126/science.2421408
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Base sequence information can be stored in the local structure of right-handed double-helical DNA (B-DNA). The question arises as to whether a set of rules for the three-dimensional readout of the B-DNA helix can be developed. This would allow the design of synthetic molecules that bind DNA of any specific sequence and site size. There are four stages of development for each new synthetic sequence-specific DNA-binding molecule: design, synthesis, testing for sequence specificity, and reevaluation of the design. This approach has produced bis(distamycin)fumaramide, a synthetic, crescent-shaped oligopeptide that binds nine contiguous adenine-thymine base pairs in the minor groove of double-helical DNA.
引用
收藏
页码:464 / 471
页数:8
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