THE POTENTIAL ROLE OF NADPH AND CYTOPLASMIC NADP-LINKED DEHYDROGENASES IN PROTECTION AGAINST SINGLET OXYGEN MEDIATED CELLULAR TOXICITY

被引：20

作者：

BODANESS, RS ^{[1
]}

机构：

[1] NEI, VIS RES LAB, BETHESDA, MD 20205 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1982年 / 108卷 / 04期

关键词：

D O I：

10.1016/S0006-291X(82)80108-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NADPH reacts efficiently with singlet oxygen (1O2), the predominant oxidation product being enzymatically active NADP. This reaction acting in concert with the cytoplasmic NADPH regenerating enzymes may contribute to the protection of cytoplasmic components against (1O2) mediated toxicity. NADP-linked isocitrate dehydrogenase [pig heart, EC 1.1.1.42] is inactivated by (1O2) photochemically generated with hematoporphyrin. When NADPH is present during photooxidation, the enzyme is protected from complete inactivation and regenerates the factor (NADPH) responsible for its own protection.

引用

页码：1709 / 1715

页数：7

共 10 条

[1]

BODANESS RS, 1977, J BIOL CHEM, V252, P8554

[2] PHOTOSENSITIZATION BY HEMATOPORPHYRIN - ESR EVIDENCE FOR FREE-RADICAL INDUCTION IN UNSATURATED FATTY-ACIDS AND FOR SINGLET OXYGEN PRODUCTION [J].