C-FPS/FES PROTEIN-TYROSINE KINASE IS IMPLICATED IN A SIGNALING PATHWAY TRIGGERED BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND INTERLEUKIN-3

被引:174
作者
HANAZONO, Y
CHIBA, S
SASAKI, K
MANO, H
MIYAJIMA, A
ARAI, K
YAZAKI, Y
HIRAI, H
机构
[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,DEPT MOLEC BIOL,PALO ALTO,CA 94330
[2] UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 108,JAPAN
关键词
C-FPS; FES PROTEIN-TYROSINE KINASE; COMMON-BETA CHAIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-3; SIGNAL TRANSDUCTION;
D O I
10.1002/j.1460-2075.1993.tb05809.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are hematopoietic growth factors which stimulate the proliferation and differentiation of myeloid progenitor cells. There is a considerable degree of overlap in target cell specificity and the functional effects of GM-CSF and IL-3. GM-CSF and IL-3 induce a nearly identical pattern of protein-tyrosine phosphorylation in certain cell lines, although their receptors have no kinase domains. Furthermore, their receptor complexes share one subunit (designated as beta). These observations raise the possibility that GM-CSF and IL-3 have a common signaling pathway. Here we show that both GM-CSF and IL-3 induce tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product (p92c-fes), a non-receptor protein-tyrosine kinase, in a human erythroleukemia cell line, TF-1, which requires GM-CSF or IL-3 for growth. In addition, GM-CSF induces physical association between p92c-fe' and the beta chain of the GM-CSF receptor. p92c-fes is therefore a possible signal transducer of several hematopoietic growth factors including GM-CSF and IL-3 through the common beta chain.
引用
收藏
页码:1641 / 1646
页数:6
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