CERULOPLASMIN STIMULATES NADH OXIDATION OF PIG-LIVER PLASMA-MEMBRANE

被引：21
作者：
ALCAIN, FJ
VILLALBA, JM
LOW, H
CRANE, FL
NAVAS, P
机构：
[1] UNIV CORDOBA,DEPT BIOL CELULAR,E-14004 CORDOBA,SPAIN
[2] KAROLINSKA INST,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN
[3] PURDUE UNIV,DEPT BIOL SCI,W LAFAYETTE,IN 47907
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)90838-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NADH oxidation by pig liver plasma membranes is stimulated by ceruloplasmin (CUP) reaching a maximal value at 50 U/ml of CUP. NADH oxidation activated by CUP is proportional to the amount of protein. Concanavalin A (Con A) which recognizes the glucidic residues of the CUP required for binding to the receptor inhibits the NADH oxidation in a dose-responsive manner. Both adriamycin and bathophenantroline disulfonate (BPS), previously reported as transplasma membrane electron transport inhibitors, also inhibit the CUP-stimulated NADH oxidation of pig liver plasma membranes. Our results show a clear interaction between CUP and the NADH oxidase of plasma membrane, which supports an oxidative role for CUP in its growth effect. © 1992.
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页码：951 / 955
页数：5
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