LIF - LOTS OF INTERESTING FUNCTIONS

被引：210

作者：

HILTON, DJ

机构：

[1] Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 02期

关键词：

D O I：

10.1016/0968-0004(92)90505-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukaemia inhibitory factor (LIF) is one of a growing number of cytokines that cannot be readily categorized according to its functions. Rather, these pleiotropic hormones have diverse and often overlapping effects on a multitude of cell types: for example, LIF can inhibit the differentiation of embryonal stem cells on one hand and induce the differentiation of M1 leukaemic cells on the other. Recent work has shed light on the physiological effects of LIF, how these are limited, and the biochemical and biological properties of LIF and its receptor.

引用

页码：72 / 76

页数：5

共 36 条

[1]

BAUMANN H, 1990, MOL BIOL MED, V7, P147

[2]

BAUMANN H, 1987, J BIOL CHEM, V262, P9756

[3]

BAUMANN H, 1991, J BIOL CHEM, V266, P20424

[4] NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD [J].