SEIZURES IN PATIENTS WITH TRISOMY-21

被引：0

作者：

ROMANO, C ^{[1
]}

TINE, A ^{[1
]}

FAZIO, G ^{[1
]}

RIZZO, R ^{[1
]}

COLOGNOLA, RM ^{[1
]}

SORGE, G ^{[1
]}

BERGONZI, P ^{[1
]}

PAVONE, L ^{[1
]}

机构：

[1] UNIV CATANIA,DEPT PEDIAT,I-95124 CATANIA,ITALY

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1990年

关键词：

FEBRILE SEIZURES; AFEBRILE SEIZURES TRISOMY-21;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report on the incidence of seizures in 113 patients with Down Syndrome (DS), 43 coming from the OASI Institute for Research on Mental Retardation and Brain Aging, Troina, and 70 from the outpatient clinic of the Department of Pediatrics, University of Catania. We obtained the following results: 15 (13.2%) patients had seizures; 6 (5.3%) febrile seizures (FS) and 9 (7.9%) afebrile seizures (aFS). Among the latter group 2 patients had generalized tonic-clonic seizures, 3 partial complex seizures, and 4 infantile spasms. The seizures appeared early in life. Only 2 adult patients had seizures. These results suggest that patients with DS show a higher incidence of FS and of aFS than non-DS individuals. Seizures in DS may be an epiphenomenon of the neurological abnormalities, both anatomical and functional, usually observed in these patients.

引用

页码：298 / 300

页数：3

共 19 条

[1]

AIRD RB, 1984, EPILEPSIES CRITICAL, P308

[2]

BALAZS R, 1986, NEUROBIOLOGY DOWN SY, P59

[3]

CAMARASA IF, 1954, REV EXP OTONEUROOFTA, V73, P199

[4] INFANTILE SPASMS ASSOCIATED WITH 5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PATIENTS WITH DOWNS SYNDROME [J].