BEHAVIORAL INDICATIONS FOR SEROTONIN RECEPTOR HYPERSENSITIVITY IN PANIC DISORDER

被引：134

作者：

KAHN, RS ^{[1
]}

WETZLER, S ^{[1
]}

VANPRAAG, HM ^{[1
]}

ASNIS, GM ^{[1
]}

STRAUMAN, T ^{[1
]}

机构：

[1] MONTEFIORE MED CTR, ALBERT EINSTEIN COLL MED, DEPT PSYCHIAT, KLAV 1, 111 E 210 ST, BRONX, NY 10467 USA

来源：

PSYCHIATRY RESEARCH | 1988年 / 25卷 / 01期

关键词：

D O I：

10.1016/0165-1781(88)90163-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

引用

页码：101 / 104

页数：4

共 13 条

[1]

[Anonymous], 1971, Edits manual for the profile of mood states

[2] NEUROBIOLOGICAL MECHANISMS IN HUMAN ANXIETY - EVIDENCE SUPPORTING CENTRAL NORADRENERGIC HYPERACTIVITY [J].