GALANIN-INDUCED GROWTH-HORMONE SECRETION IN CONSCIOUS RATS - EVIDENCE FOR A POSSIBLE INVOLVEMENT OF SOMATOSTATIN

被引：21
作者：
TANOH, T
SHIMATSU, A
ISHIKAWA, Y
IHARA, C
YANAIHARA, N
IMURA, H
机构：
[1] KYOTO UNIV,FAC MED,DEPT INTERNAL MED,DIV 2,54 SHOGOIN KAWAHARA CHO,SAKYO KU,KYOTO 606,JAPAN
[2] UNIV SHIZUOKA,SCH PHARMACEUT SCI,SHIZUOKA 422,JAPAN
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 1993年 / 5卷 / 02期
关键词：
GALANIN; GROWTH HORMONE; SOMATOSTATIN; CYSTEAMINE; ANTI-SOMATOSTATIN SERUM;
D O I：
10.1111/j.1365-2826.1993.tb00379.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.
引用
收藏
页码：183 / 187
页数：5
相关论文
共 35 条
[1]   BLOCKADE OF STRESS-INDUCED DECREASE IN BLOOD GH BY ANTI-SOMATOSTATIN SERUM IN RATS [J].
ARIMURA, A ;
SMITH, WD ;
SCHALLY, AV .
ENDOCRINOLOGY, 1976, 98 (02) :540-543
[2]   EPINEPHRINE MEDIATES THE GROWTH HORMONE-RELEASING EFFECT OF GALANIN IN INFANT RATS [J].
CELLA, SG ;
LOCATELLI, V ;
DEGENNARO, V ;
BONDIOLOTTI, GP ;
PINTOR, C ;
LOCHE, S ;
PROVEZZA, M ;
MULLER, EE .
ENDOCRINOLOGY, 1988, 122 (03) :855-859
[3]   GALANIN ABOLISHES THE INHIBITORY EFFECT OF CHOLINERGIC BLOCKADE ON GROWTH HORMONE-RELEASING HORMONE-INDUCED SECRETION OF GROWTH-HORMONE IN MAN [J].
CHATTERJEE, VKK ;
BALL, JA ;
PROBY, C ;
BURRIN, JM ;
BLOOM, SR .
JOURNAL OF ENDOCRINOLOGY, 1988, 116 (02) :R1-R2
[4]   DISTRIBUTION OF GALANIN IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM AND THE RESPONSES OF GALANIN-CONTAINING NEURONAL PATHWAYS TO INJURY [J].
CHNG, JLC ;
CHRISTOFIDES, ND ;
ANAND, P ;
GIBSON, SJ ;
ALLEN, YS ;
SU, HC ;
TATEMOTO, K ;
MORRISON, JFB ;
POLAK, JM ;
BLOOM, SR .
NEUROSCIENCE, 1985, 16 (02) :343-354
[5]   THE REBOUND RELEASE OF GROWTH-HORMONE (GH) FOLLOWING SOMATOSTATIN INFUSION IN RATS INVOLVES HYPOTHALAMIC GH-RELEASING FACTOR RELEASE [J].
CLARK, RG ;
CARLSSON, LMS ;
RAFFERTY, B ;
ROBINSON, ICAF .
JOURNAL OF ENDOCRINOLOGY, 1988, 119 (03) :397-404
[6]   ULTRASTRUCTURAL EVIDENCE FOR NEURONAL REGULATION OF GROWTH-HORMONE SECRETION [J].
DAIKOKU, S ;
HISANO, S ;
KAWANO, H ;
CHIKAMORIAOYAMA, M ;
KAGOTANI, Y ;
ZHANG, R ;
CHIHARA, K .
NEUROENDOCRINOLOGY, 1988, 47 (05) :405-415
[7]   GROWTH-HORMONE (GH) RELEASE IN RESPONSE TO GH-RELEASING HORMONE IN MAN IS 3-FOLD ENHANCED BY GALANIN [J].
DAVIS, TME ;
BURRIN, JM ;
BLOOM, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (06) :1248-1252
[8]   ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMICAL EVIDENCE FOR THE EXISTENCE OF BIDIRECTIONAL SYNAPTIC CONNECTIONS BETWEEN GROWTH HORMONE-RELEASING HORMONE-CONTAINING AND SOMATOSTATIN-CONTAINING NEURONS IN THE HYPOTHALAMUS OF THE RAT [J].
HORVATH, S ;
PALKOVITS, M ;
GORCS, T ;
ARIMURA, A .
BRAIN RESEARCH, 1989, 481 (01) :8-15
[9]   INHIBITION BY GASTRIN-RELEASING PEPTIDE OF GROWTH-HORMONE (GH) SECRETION INDUCED BY HUMAN PANCREATIC GH-RELEASING FACTOR IN RATS [J].
KABAYAMA, Y ;
KATO, Y ;
SHIMATSU, A ;
OHTA, H ;
YANAIHARA, N ;
IMURA, H .
ENDOCRINOLOGY, 1984, 115 (02) :649-653
[10]   INHIBITORY EFFECT OF HYPOTHALAMIC MEDIAL PREOPTIC AREA SOMATOSTATIN ON GROWTH HORMONE-RELEASING FACTOR IN THE RAT [J].
KATAKAMI, H ;
DOWNS, TR ;
FROHMAN, LA .
ENDOCRINOLOGY, 1988, 123 (02) :1103-1109
1234