NO EFFECT OF FACTOR-XA OR TISSUE THROMBOPLASTIN AND FACTOR-VII ON ACTIVATION OF PLASMINOGEN

被引：2
作者：
WIMAN, B
HOLM, T
PRYDZ, H
机构：
[1] UNIV UMEA, DEPT MED CHEM, S-90185 UMEA, SWEDEN
[2] UNIV TROMSO, INST MED BIOL, N-9001 TROMSO, NORWAY
来源：
THROMBOSIS RESEARCH | 1976年 / 9卷 / 05期
关键词：
D O I：
10.1016/0049-3848(76)90208-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A fast and simple method for quantitative determination of the Glu-plasminogen/Lys-plasminogen ratio was developed, in order to study a possible transformation between the plasminogen forms. Plasminogen [human] was incubated with factor Xa with and without cephalin and Ca2+ and with factor VII in presence of tissue thromboplastin. Samples were taken at different times. Urokinase was added to a final concentration of 1000 Ploug units/ml and the samples were incubated further for 15 min at 25.degree. C. The plasmin activity was determined and compared with a standard curve obtained by a similar activation of plasminogen samples with known Glu-plasminogen/Lys-plasminogen ratios. No effect was demonstrated by any of the coagulation factors tested.
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收藏
页码：523 / 525
页数：3
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