Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?

被引：2
|
作者：
Zheng, Song Guo [1 ]
机构：
[1] Univ Southern Calif, Keck Sch Med, Dept Med, Div Rheumatol & Immunol, Los Angeles, CA 90033 USA
来源：
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2013年 / 2卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
T helper cells; Th1; Th2; Th9; Th17; Tfh; Foxp3(+) regulatory T cells; cytokine; differentiation; autoimmunity;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Naive CD4(+) cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-beta suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3(+) regulatory T cells depending upon the presence of other cytokines. IL-6 promotes Th17, but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-beta-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. Here an update of T cell differentiation and conversion, as well as underlying mechanisms are given.
引用
收藏
页码：94 / 106
页数：13
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