Calcitonin-negative neuroendocrine tumor of thyroid gland mimicking anaplastic carcinoma: an unusual entity

被引：12

作者：

Ismi, Onur ^{[1
]}

Arpaci, Rabia Bozdogan ^{[2
]}

Berkesoglu, Mustafa ^{[3
]}

Dag, Ahmet ^{[3
]}

Sezer, Emel ^{[4
]}

Bal, Kemal Koray ^{[1
]}

Vayisoglu, Yusuf ^{[1
]}

机构：

[1] Mersin Univ, Fac Med, Dept Otorhinolaryngol, Mersin, Turkey

[2] Mersin Univ, Fac Med, Dept Pathol, Mersin, Turkey

[3] Mersin Univ, Fac Med, Dept Gen Surg, Mersin, Turkey

[4] Mersin Univ, Fac Med, Dept Med Oncol, Mersin, Turkey

来源：

GLAND SURGERY | 2015年 / 4卷 / 04期

关键词：

Neuroendocrine tumor (NET); thyroid; medullary thyroid carcinoma (MTC); calcitonin;

D O I：

10.3978/j.issn.2227-684X.2015.01.02

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Medullary thyroid cancer is the neuroendocrine tumor (NET) of thyroid with mostly both secreting calcitonin and immunohistochemically showing calcitonin positivity. Occasionally; NETs of thyroid may have little or no calcitonin expression. We present a case of serum calcitonin negative and immunohistochemically calcitonin-negative staining tumor with positive reaction to neuroendocrine markers synaptophysin and chromogranin-A. The patient's right vocal cord was paralytic and thyroid mass was huge with descending to thorax till hilar region. We discussed diagnostic difficulties and way of treatment about NETs of thyroid with the light of current literature with this case.

引用

页码：344 / 349

页数：6

共 13 条

[1] Evaluation of a Thyroid Nodule [J].

Bomeli, Steven R. ;

LeBeau, Shane O. ;

Ferris, Robert L. .

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2010, 43 (02) :229-+

[2] Calcitonin-Negative Neuroendocrine Tumor of the Thyroid: A Distinct Clinical Entity [J].

Chernyavsky, Victoriya S. ;

Farghani, Saima ;

Davidov, Tomer ;

Ma, Ly ;

Barnard, Nicola ;

Amorosa, Louis F. ;

Trooskin, Stanley Z. .

THYROID, 2011, 21 (02) :193-196

[3]

Cornetta AJ, 2003, ENT-EAR NOSE THROAT, V82, P388

[4]

Cornetta Anthony J, 2003, Ear Nose Throat J, V82, P384

[5] Small-Cell (Basaloid) Thyroid Carcinoma: A Neoplasm With a Solid Cell Nest Histogenesis? [J].

Cruz, Joao ;

Eloy, Catarina ;

Araguees, Jose Maria ;

Vinagre, Joao ;

Sobrinho-Simoes, Manuel .

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2011, 19 (05) :620-626

[6] CALCITONIN FREE OAT-CELL CARCINOMA OF THE THYROID-GLAND [J].

EUSEBI, V ;

DAMIANI, S ;

RIVA, C ;

LLOYD, RV ;

CAPELLA, C .

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1990, 417 (03) :267-271

[7] Neuroendocrine Tumors: Beyond the Abdomen [J].

Jacobs, Melissa A. ;

Weinstein, Stefanie ;

Hope, Thomas A. ;

Aslam, Rizwan ;

Yee, Judy ;

Coakley, Fergus .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2014, 38 (06) :898-914

[8] C-Cell-Derived Calcitonin-Free Neuroendocrine Carcinoma of the Thyroid: The Diagnostic Importance of CGRP Immunoreactivity [J].

Nakazawa, Tadao ;

Cameselle-Teijeiro, Jose ;

Vinagre, Joao ;

Soares, Paula ;

Rousseau, Emmanuel ;

Eloy, Catarina ;

Sobrinho-Simoes, Manuel .

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2014, 22 (06) :530-535

[9] Medullary Thyroid Carcinoma [J].

Pacini, F. ;

Castagna, M. G. ;

Cipri, C. ;

Schlumberger, M. .

CLINICAL ONCOLOGY, 2010, 22 (06) :475-485

[10] Atypical medullary thyroid carcinoma with little or no calcitonin expression [J].

Schmid, KW ;

Ensinger, C .

VIRCHOWS ARCHIV, 1998, 433 (03) :209-215

← 1 2 →