ANTIPSYCHOTIC-DRUGS - DIRECT CORRELATION BETWEEN CLINICAL POTENCY AND PRESYNAPTIC ACTION ON DOPAMINE NEURONS

被引:709
作者
SEEMAN, P [1 ]
LEE, T [1 ]
机构
[1] UNIV TORONTO, PHARMACOL DEPT, TORONTO M5S 1A8, ONTARIO, CANADA
关键词
D O I
10.1126/science.1145194
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1217 / 1219
页数:3
相关论文
共 45 条
[1]  
Aghajanian G.K., 1974, FRONT NEUROL, P4
[2]   EFFECT OF NEUROLEPTIC DRUGS ON CENTRAL CATECHOLAMINE TURNOVER ASSESSED USING TYROSINE-BETA-HYDROXYLASE AND DOPAMINE-BETA-HYDROXYLASE INHIBITORS [J].
ANDEN, NE ;
CORRODI, H ;
FUXE, K .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (03) :177-&
[3]   IMPORTANCE OF NERVOUS IMPULSE FLOW FOR NEUROLEPTIC INDUCED INCREASE IN AMINE TURNOVER IN CENTRAL DOPAMINE NEURONS [J].
ANDEN, NE ;
CORRODI, H ;
FUXE, K ;
UNGERSTEDT, U .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1971, 15 (02) :193-+
[4]   RECEPTOR ACTIVITY AND TURNOVER OF DOPAMINE AND NORADRENALINE AFTER NEUROLEPTICS [J].
ANDEN, NE ;
BUTCHER, SG ;
CORRODI, H ;
FUXE, K ;
UNGERSTEDT, U .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1970, 11 (03) :303-+
[5]   NEUROLEPTIC AGENTS OF BENZOCYCLOHEPTAPYRIDOISOQUINOLINE SERIES .1. SYNTHESES AND STEREOCHEMICAL AND STRUCTURAL REQUIREMENTS FOR ACTIVITY OF BUTACLAMOL AND RELATED COMPOUNDS [J].
BRUDERLEIN, FT ;
HUMBER, LG ;
VOITH, K .
JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (02) :185-188
[6]  
BUNNEY BS, 1973, J PHARMACOL EXP THER, V185, P560
[7]  
CARLSSON A, 1963, ACTA PHARMACOL TOX, V20, P140
[8]   DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN MAMMALIAN BRAIN - POSSIBLE SITE OF ACTION OF ANTIPSYCHOTIC-DRUGS [J].
CLEMENTC.YC ;
KEBABIAN, JW ;
PETZOLD, GL ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (04) :1113-1117
[9]  
FARNEBO LO, 1971, ACTA PHYSIOL SCAND, P19
[10]  
FARNEBO LO, 1971, ACTA PHYSIOL SCAND, P35