Stromal TGF beta R2 signaling: a gateway to progression for pancreatic cancer

被引：3
|
作者：
Hagopian, Moriah M. [1 ,2 ]
Brekken, Rolf A. [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Div Surg Oncol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 03期
关键词：
epithelial to mesenchymal transition; metastasis; pancreatic cancer; TGF-beta; tumor-stroma interactions;
D O I：
10.4161/23723556.2014.975606
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The function of transforming growth factor beta (TGF beta) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgf beta r2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.
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页数：3
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