Stromal TGF beta R2 signaling: a gateway to progression for pancreatic cancer

被引：3
|
作者：
Hagopian, Moriah M. [1 ,2 ]
Brekken, Rolf A. [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Div Surg Oncol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 03期
关键词：
epithelial to mesenchymal transition; metastasis; pancreatic cancer; TGF-beta; tumor-stroma interactions;
D O I：
10.4161/23723556.2014.975606
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The function of transforming growth factor beta (TGF beta) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgf beta r2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Inhibition of Stromal TGFβR2 Inhibits Pancreatic Cancer Growth and Metastasis In Vivo
    Ostapoff, K. T.
    Cenik, B.
    Schwarz, R. E.
    Brekken, R. A.
    ANNALS OF SURGICAL ONCOLOGY, 2013, 20 : S33 - S33
  • [2] a TGFβR2 Inhibitor, Blocks TGF-β Signaling and Migration in an Immunocompetent Pancreatic Cancer Model
    Ostapoff, K. T.
    Cenik, B.
    Schwarz, R. E.
    Brekken, R. A.
    ANNALS OF SURGICAL ONCOLOGY, 2012, 19 : S19 - S19
  • [3] Stromal LOX promotes TGFβR2 null breast cancer metastasis
    Pickup, Micheal W.
    Owena, Philip
    Gorska, Agnes
    Chytil, Anna
    Weaver, Valerie
    Moses, Harold
    CANCER RESEARCH, 2013, 73
  • [4] Stromal and epithelial TGF-beta signaling in cancer.
    Moses, Harold L.
    CANCER RESEARCH, 2006, 66 (08)
  • [5] Stromal response to Hedgehog signaling restrains pancreatic cancer progression
    Lee, John J.
    Perera, Rushika M.
    Wang, Huaijun
    Wu, Dai-Chen
    Liu, X. Shawn
    Han, Shiwei
    Fitamant, Julien
    Jones, Phillip D.
    Ghanta, Krishna S.
    Kawano, Sally
    Nagle, Julia M.
    Deshpande, Vikram
    Boucher, Yves
    Kato, Tomoyo
    Chen, James K.
    Willmann, Juergen K.
    Bardeesy, Nabeel
    Beachy, Philip A.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (30) : E3091 - E3100
  • [6] Effect of 2G8, a TGF-beta-R2 inhibitor, on TGF-beta signaling and migration in an immunocompetent pancreatic cancer model.
    Ostapoff, Katherine
    Cenik, Bercin
    Schwarz, Roderich
    Brekken, Rolf A.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (04)
  • [7] eTargeting stromal autotaxin synergizes with TGF beta inhibition in pancreatic cancer
    Sabbadini, Fabio
    Bertolini, Monica
    Mangiameli, Domenico
    Contarelli, Serena
    Johnson, Zoe
    Lahn, Michael M.
    Pietrobono, Silvia
    Melisi, Davide
    CANCER RESEARCH, 2022, 82 (12)
  • [8] Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
    Huang, Huocong
    Zhang, Yuqing
    Gallegos, Valerie
    Sorrelle, Noah
    Zaid, Mohamed Medhat
    Toombs, Jason
    Du, Wenting
    Wright, Steven
    Hagopian, Moriah
    Wang, Zhaoning
    Hosein, Abdel Nasser
    Sathe, Adwait Amod
    Xing, Chao
    Koay, Eugene J.
    Driscoll, Kyla E.
    Brekken, Rolf A.
    EMBO MOLECULAR MEDICINE, 2019, 11 (11)
  • [9] SMAD4 and TGFβR2 expression in pancreatic ductal carcinoma
    Vaduva, Ion Alexandru
    Margaritescu, Claudiu
    Georgescu, Claudia-Valentina
    Enache, Andreea-Oana
    Padureanu, Rodica
    Saftoiu, Adrian
    Pirici, Daniel
    ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2019, 60 (03): : 803 - 809
  • [10] Neutralizing Murine TGFβR2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis
    Ostapoff, Katherine T.
    Cenik, Bercin Kutluk
    Wang, Miao
    Ye, Risheng
    Xu, Xiaohong
    Nugent, Desiree
    Hagopian, Moriah M.
    Topalovski, Mary
    Rivera, Lee B.
    Carroll, Kyla D.
    Brekken, Rolf A.
    CANCER RESEARCH, 2014, 74 (18) : 4996 - 5007
12345