BIOPHYSICAL APPROACHES TO SALIVARY MUCIN STRUCTURE, CONFORMATION AND DYNAMICS

被引:17
作者
GERKEN, TA
机构
关键词
SUBMAXILLARY MUCINS; O-LINKED GLYCOPROTEINS; GLYCOPROTEIN CONFORMATION; LIGHT SCATTERING; NUCLEAR MAGNETIC RESONANCE; MOLECULAR MODELING; MOLECULAR DIMENSIONS;
D O I
10.1177/10454411930040030201
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Our understanding of the origins of the physical and biochemical properties of mucous glycoproteins is incomplete and not with out controversy. Recent molecular biological and biophysical studies revealing the architecture and solution structure and dynamics of a series of salivary mucins, invaluable toward resolving many of these questions, are discussed. Mucins are very large, structurally heterogeneous, and highly expanded molecules with the carbohydrate playing a key role in maintaining the extended mucin conformation.
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页码:261 / 270
页数:10
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