PATTERNS AND SEVERITY OF CONDUCTION ABNORMALITIES IN GUILLAIN-BARRE-SYNDROME

被引:71
作者
BROWN, WF
SNOW, R
机构
[1] Clinical Neurological Sciences, University Hospital, London, ON N6A 5A5
关键词
D O I
10.1136/jnnp.54.9.768
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Whether the conduction abnormalities and lesions underlying them are. randomly distributed throughout the peripheral nervous system (PNS) or certain regions are selectively more vulnerable to attack is an unresolved question in Guillain-Barre syndrome (GBS). To examine this question, 15 cases of GBS were comprehensively examined using electrophysiological techniques which allowed close examination, quantitation and comparison of conduction abnormalities in motor and sensory fibres of the upper limb between the spinal cord and the distal extremities of the nerve fibres. Comparison of these studies with results expected in a model where the chances of conduction failure were uniformly distributed led to the conclusion that conduction slowing and block were not uniformly distributed in most cases. Conduction block, was maximal in the terminal segment distal to the wrist and to a lesser extent both conduction block and conduction slowing were disproportionately greater across the elbow and in the axillary to spinal root segments in over one half of the cases. These findings support the hypothesis that certain regions, perhaps because of relative deficiencies of the blood-nerve barrier, may be more vulnerable in GBS than other regions.
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页码:768 / 774
页数:7
相关论文
共 22 条
[1]   INFLAMMATORY LESION IN IDIOPATHIC POLYNEURITIS - ITS ROLE IN PATHOGENESIS [J].
ASBURY, AK ;
ARNASON, BG ;
ADAMS, RD .
MEDICINE, 1969, 48 (03) :173-&
[2]   DIAGNOSTIC CONSIDERATIONS IN GUILLAIN-BARRE-SYNDROME [J].
ASBURY, AK .
ANNALS OF NEUROLOGY, 1981, 9 :1-5
[3]   REVERSIBLE PROXIMAL CONDUCTION BLOCK UNDERLIES RAPID RECOVERY IN GUILLAIN-BARRE-SYNDROME [J].
BERGER, AR ;
LOGIGIAN, EL ;
SHAHANI, BT .
MUSCLE & NERVE, 1988, 11 (10) :1039-1042
[4]   CONDUCTION BLOCK AND DENERVATION IN GUILLAIN-BARRE POLYNEUROPATHY [J].
BROWN, WF ;
FEASBY, TE .
BRAIN, 1984, 107 (MAR) :219-239
[5]   SENSORY EVOKED-POTENTIALS IN GUILLAIN-BARRE POLYNEUROPATHY [J].
BROWN, WF ;
FEASBY, TE .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1984, 47 (03) :288-291
[6]  
BROWN WF, 1984, PHYSL TECHNICAL BASI
[7]   HISTOLOGICAL FINE STRUCTURE OF PERINEURIUM [J].
BURKEL, WE .
ANATOMICAL RECORD, 1967, 158 (02) :177-+
[8]   MOTOR CONDUCTION STUDIES IN GUILLAIN-BARRE-SYNDROME - DESCRIPTION AND PROGNOSTIC VALUE [J].
CORNBLATH, DR ;
MELLITS, ED ;
GRIFFIN, JW ;
MCKHANN, GM ;
ALBERS, JW ;
MILLER, RG ;
FEASBY, TE ;
QUASKEY, SA .
ANNALS OF NEUROLOGY, 1988, 23 (04) :354-359
[9]   AXONAL CONDUCTION-VELOCITY AND FORCE OF SINGLE HUMAN MOTOR UNITS [J].
DENGLER, R ;
STEIN, RB ;
THOMAS, CK .
MUSCLE & NERVE, 1988, 11 (02) :136-145
[10]  
ERLINGER J, 1946, AM J PHYSIOL, V147, P550