MODULATORY EFFECTS OF CROCUS-SATIVUS AND NIGELLA-SATIVA EXTRACTS ON CISPLATIN-INDUCED TOXICITY IN MICE

被引：74

作者：

NAIR, SC ^{[1
]}

SALOMI, MJ ^{[1
]}

PANIKKAR, B ^{[1
]}

PANIKKAR, KR ^{[1
]}

机构：

[1] AMALA CANC RES CTR,TRICHUR 680553,KERALA,INDIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 31卷 / 01期

关键词：

D O I：

10.1016/0378-8741(91)90146-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In mice, an extract of Crocus sativus stigmas partially prevented the decreases in body weight, hemoglobin levels and leucocyte counts caused by 2 mg/kg of cisplatin i.p. for 5 days. Treatment with the C. sativus extract also significantly prolonged the life span of cisplatin-treated mice almost three-fold. In contrast, an extract of Nigella sativa seed only tended to protect from cisplatin-induced falls in hemoglobin levels and leucocyte counts.

引用

页码：75 / 83

页数：9

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