A ROLE OF PROSTAGLANDIN IN THE SECRETION OF INHIBIN AND ESTRADIOL-17-BETA IN EQUINE CHORIONIC GONADOTROPIN-PRIMED RATS

被引：7

作者：

KOGO, H ^{[1
]}

TAKASAKI, K ^{[1
]}

TAKEO, S ^{[1
]}

WATANABE, G ^{[1
]}

TAYA, K ^{[1
]}

SASAMOTO, S ^{[1
]}

机构：

[1] TOKYO UNIV AGR & TECHNOL,VET PHYSIOL LAB,FUCHU,TOKYO 183,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 231卷 / 03期

关键词：

INHIBIN; ESTRADIOL-17-BETA; OVARIAN HORMONES; GONADOTROPIN; PROSTAGLANDIN-F2-ALPHA; INDOMETHACIN;

D O I：

10.1016/0014-2999(93)90129-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of prostaglandins in the secretion of inhibin and oestradiol-17beta was examined in immature female rats treated with equine chorionic gonadotrophin. Administration of prostaglandin (PG) F2alpha to animals whose serum and ovarian levels of inhibin and oestradiol-17beta had been suppressed by indomethacin given 24 h after equine chorionic gonadotrophin prevented the inhibition or restored the levels to normal. Initiation of PGF2alpha replacement immediately after treatment with indomethacin was more effective. The results are consistent with the hypothesis that PGs play a regulatory role in the synthesis and secretion of inhibin and oestradiol-17beta by the rat ovary.

引用

页码：481 / 484

页数：4

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